7-methoxynaphthalene-2-sulfonyl Chloride → HCID 54346822, compound

HRID 651625Notes

Reaction equation

HRID 651625 reaction equation
[NH2:1][C@H:2]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([N+:16]([O-:18])=[O:17])[CH:10]=2)[C:3]1=[O:19].[CH3:20][O:21][C:22]1[CH:31]=[C:30]2[C:25]([CH:26]=[CH:27][C:28]([S:32](Cl)(=[O:34])=[O:33])=[CH:29]2)=[CH:24][CH:23]=1>C(Cl)Cl>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][N:4]2[CH2:5][CH2:6][C@H:2]([NH:1][S:32]([C:28]3[CH:27]=[CH:26][C:25]4[C:30](=[CH:31][C:22]([O:21][CH3:20])=[CH:23][CH:24]=4)[CH:29]=3)(=[O:34])=[O:33])[C:3]2=[O:19])=[CH:10][C:11]=1[N+:16]([O-:18])=[O:17]

Participants

4

Reactant 2

HCID 105152667-methoxynaphthalene-2-sulfonyl ChlorideHCID 20680709HCID 20680709, compound

Product 1

HCID 54346822HCID 54346822, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared in CH2Cl2 instead of CH3CN as described in EXAMPLE 1, Part K using 3-(S)-amino-1-[2-(4-amino-3-nitrophenyl)-ethyl]-pyrrolidin-2-one in place of 7-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)-1-chloro-isoquinoline hydrochloride and 7-methoxynaphthalene-2-sulfonyl chloride as prepared in EXAMPLE 1, Part J. After similar workup, the organic phase is concentrated in vacuo to afford the title compound as a pale yellow solid which is used as is in the subsequent step.

Workup

  1. customas prepared in EXAMPLE 1, Part J
  2. concentrationAfter similar workup, the organic phase is concentrated in vacuo

Sources & evidence

ORD record
ord-7c17844bfc7847e78b267db64b8d8147
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Reaction notes

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