Propargyl bromide → HCID 53895069, compound

HRID 651653Notes

Reaction equation

HRID 651653 reaction equation
[C:1]([O:5][C:6](=[O:14])[NH:7][C@H:8]1[CH2:12][CH2:11][NH:10][C:9]1=[O:13])([CH3:4])([CH3:3])[CH3:2].[CH2:15](Br)[C:16]#[CH:17]>>[C:1]([O:5][C:6](=[O:14])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([CH2:17][C:16]#[CH:15])[C:9]1=[O:13])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 7842Propargyl bromideHCID 10750535(S)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate

Product 1

HCID 53895069HCID 53895069, compound

Procedure

The title compound is prepared from (2-oxopyrrolidin-3-(S)-yl)-carbamic acid tert-butyl ester as described in EXAMPLE 1, Part H using propargyl bromide in place of 7-bromomethyl-1-chloro-isoquinoline. The crude product is triturated from Et2O/hexanes to give the title compound as a white solid.

Workup

  1. customThe crude product is triturated from Et2O/hexanes

Sources & evidence

ORD record
ord-45778741c80c43e8a0f97f7054810def
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Reaction notes

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