Benzyl [(3S)-2-oxopyrrolidin-3-yl]carbamate → HCID 54477422, compound

HRID 651667Notes

Reaction equation

HRID 651667 reaction equation
Br[CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[C:10]2[O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:5][CH:4]=1.[CH2:20]([O:27][C:28](=[O:36])[NH:29][C@H:30]1[CH2:34][CH2:33][NH:32][C:31]1=[O:35])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:20]([O:27][C:28](=[O:36])[NH:29][C@H:30]1[CH2:34][CH2:33][N:32]([CH2:2][C:3]2[CH:12]=[C:11]3[C:6]([CH:7]=[CH:8][N:9]=[C:10]3[O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:5][CH:4]=2)[C:31]1=[O:35])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 11447643Benzyl [(3S)-2-oxopyrrolidin-3-yl]carbamateHCID 181764157-Bromomethyl-1-phenoxyisoquinoline

Product 1

HCID 54477422HCID 54477422, compound

Procedure

The title compound is prepared as described in Example 1, Part H using 7-bromomethyl-1-phenoxyisoquinoline and [2-oxopyrrolidin-3-(S)-yl]carbamic acid benzyl ester as the starting materials. The crude product is purified by column chromatography eluting with 70% EtOAc/hexanes to afford the title product as a clear oil.

Workup

  1. customThe title compound is prepared
  2. customThe crude product is purified by column chromatography
  3. washeluting with 70% EtOAc/hexanes

Sources & evidence

ORD record
ord-d50dc585bdef430c947052e625e16909
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Reaction notes

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