Methanol → HCID 20680717, compound

HRID 651687Notes

Reaction equation

HRID 651687 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([NH2:19])=[N:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[C:4]1=[O:20].CO>ClCCl>[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([NH2:19])=[N:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[C:4]1=[O:20]

Participants

4

Reactant 2

HCID 887MethanolHCID 20680716HCID 20680716, compound

Product 1

HCID 20680717HCID 20680717, compoundYield 76.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-(S)-Amino-1-(4-Aminoquinazolin-7-ylmethyl)pyrrolidin-2-one hydrochloride (600 mg, 1.82 mmol) is chromatographed on silica with 12% methanol/2% ammonium hydroxide (28% aqueous)/86% dichloromethane, and the product fractions combined and concentrated to give the free base as a pale yellow powder (360 mg, 1.4 mmol).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-da8dcd65ee2d458fb9b5661b3a7d76ce
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Reaction notes

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