Mechlorethamine → 1-Methylpiperidine-4,4-dicarbonitrile

Participants

Reaction Steps

A mixture of 31.2 g of bis(chloroethyl)methylamine, 13.2 g of malonitrile, 55.28 g of potassium carbonate and 800 ml of acetonitrile is refluxed on a steam bath for 24 hours, then filtered while hot. The filtrate is evaporated and the residue crystallized with charcoal treatment from 100 ml of ethanol, giving 10.6 g of 1-methylpiperidine-4,4-dicarbonitrile, as colorless crystals.

Provenance & Evidence