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Hydrochloric Acid → 3-[6-(1H-Imidazol-2-yl)-1-methyl-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 1-methyl-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1H-indole | HCID 21709055 | — |
| 反応物 | Isopropyl 1-methyl-3-indoleacetimidate hydrochloride | HCID 22907276 | — |
| 生成物 | 3-[6-(1H-Imidazol-2-yl)-1-methyl-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione | HCID 10202360 | 14% |
反応手順
3-[6-(1H-Imidazol-2-yl)-1-methyl-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione (37 mg, 14%) was prepared as an orange solid using 1-methyl-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1H-indole (200 mg, 0.61 mmol) and 1-methyl-3-indoleacetimidic acid isopropyl ester hydrochloride (162 mg, 0.61 mmol) followed by deprotection using 20% HCl in refluxing EtOH.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06281356B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-1cf4dfeba95747aabc7cf86752aff57a |
| 出典メモ | uspto-grants-2001_08 |