Methanol → HCID 10179559, compound

HRID 651747Notes

Reaction equation

HRID 651747 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][N:12]2[CH3:15])=[CH:8][CH:7]=1.Cl.C([O:20][C:21](=[NH:38])[CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[N:25](C(=O)C(C)(C)C)[CH:24]=1)(C)C.[CH3:39][O-:40].[Na+].[CH3:42]O>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:14]=[C:13]2[C:9]([C:10]([C:42]3[C:39](=[O:40])[NH:20][C:21](=[O:38])[C:22]=3[C:23]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[NH:25][CH:24]=3)=[CH:11][N:12]2[CH3:15])=[CH:8][CH:7]=1

Participants

5

Reactant 4

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 21709052HCID 21709052, compoundHCID 70120191HCID 70120191, compound

Product 1

HCID 10179559HCID 10179559, compound

Procedure

3-(6-Furan-2-yl-1-methyl-1H-indol-3-yl)-4-(1H-indol-3-yl)pyrrole-2,5-dione was prepared from 6-furan-2-yl-1-methyl-1H-indole and 2-[1-(2,2-dimethylpropionyl)-1H-indol-3-yl]acetimidic acid isopropyl ester hydrochloride followed by deprotection with NaOMe in methanol.

Sources & evidence

ORD record
ord-244d1e1776114aafa9d21a6591903ef9
Source dataset
uspto-grants-2001_08
Patent number
US06281356B1

Reaction notes

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