HCID 21709059, compound → HCID 10114030, compound

HRID 651749Notes

Reaction equation

HRID 651749 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:12]3[C:13](=[O:28])[NH:14][C:15](=[O:27])[C:16]=3[C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[N:19]([CH3:26])[CH:18]=3)=[CH:7][N:8]2[CH3:11])=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[S:34][C:35]1[NH:36][CH:37]=[CH:38]C=1)CCC>>[CH3:26][N:19]1[C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17]([C:16]2[C:15](=[O:27])[NH:14][C:13](=[O:28])[C:12]=2[C:6]2[C:5]3[C:9](=[CH:10][C:2]([C:35]4[S:34][CH:38]=[CH:37][N:36]=4)=[CH:3][CH:4]=3)[N:8]([CH3:11])[CH:7]=2)=[CH:18]1

Participants

3

Reactant 2

HCID 21709059HCID 21709059, compoundHCID 70101287HCID 70101287, compound

Product 1

HCID 10114030HCID 10114030, compoundYield 23%

Procedure

3-(1-Methyl-1H-indol-3-yl)-4-(1-methyl-6-thiazol-2-yl-1H-indol-3-yl)pyrrole-2,5-dione (25 mg, 23%) was prepared from 3-(6-bromo-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione (108 mg, 0.25 mmol) and 2-(tributylstannyl)thioazole (140 mg, 0.375 mmol).

Sources & evidence

ORD record
ord-42026220f0384f4a8218019f54fe773f
Source dataset
uspto-grants-2001_08
Patent number
US06281356B1

Reaction notes

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