反应详情

温度

0 °C

6-Imidazol-1-yl-1-methyl-1H-indole (0.90 g, 4.56 mmol ) was dissolved in CH2Cl2 (2 mL) and cooled at 0° C. Methyl chlorooxoacetate (1.3 mL, 14 mmol) was added. Stirring was continued for 2 h at 0° C. and more methyl chlorooxoacetate (0.4 mL, 4.3 mmol) was added. After an additional 2 h, the solvent was removed. The residual solid was taken up in ether, filtered and washed well with ether to give crude methyl (6-imidazol-1-yl-1-methyl-1H-indol-3-yl)glyoxylate (1.50 g).

1. waitAfter an additional 2 h
2. customthe solvent was removed
3. filtrationfiltered
4. washwashed well with ether