HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-6-nitro-1H-indole → 1-methyl-1H-indol-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-6-nitro-1H-indole | HCID 10607359 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-methyl-1H-indol-6-amine | HCID 10534799 | — |
Reaction Steps
A mixture of 1-methyl-6-nitro-1H-indole (5.0 g, 28.4 mmol) and 10% Pd/C(1.0 g) in ethanol (200 ml) and tetrahydrofuran (100 ml) was hydrogenated at atmospheric pressure for 14 hours. The reaction mixture was filtered and concentrated to give 1-methyl-6-amino-1H-indole after crystallization from ether/hexane (3.8 g, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06281356B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-43114244a0d84dc88471a1748567d7c5 |
| Source note | uspto-grants-2001_08 |