反应详情

温度

0 °C

1-Methyl-6-morpholin-4-yl-1H-indole (3.89 g, 18 mmol) was dissolved in CH2Cl2 (18 mL) and cooled at 0° C. Methyl chlorooxoacetate (2.4 mL, 26 mmol) was added to give a dark solution. Stirring was continued for 2 h at 0° C. and more methyl chlorooxoacetate (0.40 mL, 4.3 mmol) was added. After a further 2 h, the solvent was evaporated. The resulting solid was taken up in ether, filtered and washed well with ether to give crude methyl (1-methyl-6-morpholin-4-yl-1H-indol-3-yl)glyoxylate (6 g).

1. customto give a dark solution
2. waitAfter a further 2 h
3. customthe solvent was evaporated
4. filtrationfiltered
5. washwashed well with ether