Tetrahydrofuran → HCID 10298560, compound

Participants

Reaction Steps

A solution of t-BuOK in THF (1 M, 18.9 mL, 18.9 mmol) was added dropwise to a mixture of methyl (6-cyano-1-methyl-1H-indol-3-yl)glyoxylate (1.85 g, 7.64 mmol) and (1-methyl-6-morpholin-4-yl-1H-indol-3-yl)-acetamide (1.74 g, 6.36 mmol) at 0° C. The cooling bath was removed after 15 min and the mixture was stirred at room temperature for 3 h. Concentrated hydrochloric acid (37%, 10 mL) was added and the reaction mixture was stirred for a further 30 min. The mixture was made basic with aqueous NaHCO3 and extracted with CHCl3 (3×500 mL). The combined organic extracts were washed with aqueous Na2CO3 and dried (K2CO3). The extracts were filtered through a pad of silica gel, then evaporation of the solvents and crystallization of the crude product from acetone/EtOAc gave 1-methyl-3-[4-(1-methyl-6-morpholin-4-yl-1H-indol-3-yl)-2,5 -dioxo-2,5-dihydro-1H-pyrrole-3-yl-]-1H-indole-6-carbonitrile (2.05 g, 69%). Ref: Faul, M. M.; Winneroski, L. L.; Krumrich, C. A. J. Org. (Chem. 1998, 63, 6053.

Provenance & Evidence