HCID 21709057, compound → HCID 10164405, compound

HRID 651767Notes

Reaction equation

HRID 651767 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[CH:9]=2)[C:4]([C:15](=O)[C:16](OC)=[O:17])=[CH:3]1.[CH3:21][N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)[CH:29]=2)[C:24]([CH2:37][C:38]([NH2:40])=[O:39])=[CH:23]1>>[CH3:21][N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([N:31]3[CH2:32][CH2:33][O:34][CH2:35][CH2:36]3)[CH:29]=2)[C:24]([C:37]2[C:38](=[O:39])[NH:40][C:16](=[O:17])[C:15]=2[C:4]2[C:5]3[C:10](=[CH:9][C:8]([C:11]([F:13])([F:12])[F:14])=[CH:7][CH:6]=3)[N:2]([CH3:1])[CH:3]=2)=[CH:23]1

Participants

3

Reactant 2

HCID 21709057HCID 21709057, compoundHCID 86757287HCID 86757287, compound

Product 1

HCID 10164405HCID 10164405, compoundYield 54%

Procedure

3-(1-Methyl-6-morpholin-4-yl-1H-indol-3-yl)-4-(1-methyl-6-trifluoromethyl-1H-indol-3-yl)pyrrole-2,5-dione (151 mg, 54%) was prepared from methyl (1-methyl-6-trifluromethyl-1H-indol-3-yl)glyoxylate (172 mg, 0.60 mmol) and (1-methyl-6-morpholin-4-yl-1H-indol-3-yl)acetamide (150 mg, 0.55 mmol).

Sources & evidence

ORD record
ord-3032408bcd744ed9ba5c6c1dfdc3f611
Source dataset
uspto-grants-2001_08
Patent number
US06281356B1

Reaction notes

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