(1-methyl-6-pyrrolidin-1-yl-1H-indol-3-yl)-acetamide → 3-(6-Methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-6-pyrrolidin-1-yl-1H-indol-3-yl)pyrrole-2,5-dione

HRID 651769Notes

Reaction equation

HRID 651769 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:13](=O)[C:14]([O:16]C)=O)=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1.[CH3:19][N:20]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)[CH:27]=2)[C:22]([CH2:34][C:35]([NH2:37])=[O:36])=[CH:21]1>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:13]3[C:14](=[O:16])[NH:37][C:35](=[O:36])[C:34]=3[C:22]3[C:23]4[C:28](=[CH:27][C:26]([N:29]5[CH2:30][CH2:31][CH2:32][CH2:33]5)=[CH:25][CH:24]=4)[N:20]([CH3:19])[CH:21]=3)=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 21709040(1-methyl-6-pyrrolidin-1-yl-1H-indol-3-yl)-acetamideHCID 84741837methyl (6-methoxy-1-methyl-1H-indol-3-yl)glyoxylate

Product 1

HCID 101826473-(6-Methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-6-pyrrolidin-1-yl-1H-indol-3-yl)pyrrole-2,5-dioneYield 58%

Procedure

3-(6-Methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-6-pyrrolidin-1-yl-1H-indol-3-yl)pyrrole-2,5-dione (55 mg, 58%) was prepared from methyl (6-methoxy-1methyl -1H-indol-3-yl)-glyoxylate (57mg, 0.23 mmol) and (1-methyl-6-pyrrolidin-1-yl-1H-indol-3-yl)-acetamide (54 mg, 0.21 mmol).

Sources & evidence

ORD record
ord-68f8b666c85b4104847cf611acde0c75
Source dataset
uspto-grants-2001_08
Patent number
US06281356B1

Reaction notes

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