HCID 86757298, compound → HCID 86757297, compound

HRID 651787Notes

Reaction equation

HRID 651787 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][NH:8][C:9]([C@H:11]([CH:21]([CH2:37][CH:38]([CH3:40])[CH3:39])[C:22]([NH:24][N:25]1[C:29](=[O:30])[C:28]2([CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[NH:27][C:26]1=[O:36])=[O:23])[CH2:12][CH:13]=[CH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10].[H][H]>CO.[Pd]>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:37][CH:38]([CH3:40])[CH3:39])[C:22]([NH:24][N:25]1[C:29](=[O:30])[C:28]2([CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[NH:27][C:26]1=[O:36])=[O:23])[CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10]

Participants

5

Reactant 2

HCID 86757298HCID 86757298, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86757297HCID 86757297, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 0.25 g of (E)-2(R(-[1(S)-[(tetrahydro-2(RS)pyranyloxy)carbamoyl]4-phenyl-3-butenyl]-4-methyl-N-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)valeramide in 5 ml of methanol containing 0.025 g of 10% palladium-on-carbon catalyst was shaken in a hydrogen atmosphere for 2 hours. The catalyst was filtered off to give a solution of 0.25 g of 2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenylbutyl]-4-methyl-N-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)valeramide in methanol that was used directly in the process step.

Workup

  1. filtrationThe catalyst was filtered off

Sources & evidence

ORD record
ord-c5c1dcb033de45f583abc6440f1d5a02
Source dataset
uspto-grants-2001_08
Patent number
US06281363B1

Reaction notes

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