HCID 20681537, compound → HCID 70203736, compound

Participants

Reaction Steps

A solution of 1.01 g of benzyl 3-[2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-4-methylvaleramido]-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate in 15 ml of methanol was treated with 0.432 g of 10% palladium-on-charcoal catalyst. The mixture was shaken in a hydrogen atmosphere for 18 hours. The catalyst was filtered off and the methanol evaporated. The residue was triturated with ether and there was obtained 0.81 g of 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-4-methyl-N-[2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]valeramide in the form of a white solid.

Provenance & Evidence