Benzenesulfonyl chloride → HCID 70238143, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 26, part (i) but using benzenesulphonyl chloride in place of methanesulphonyl chloride from 0.83 g of 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-4-methyl-N-[2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]valeramide there was obtained 0.889 g of N-[8-(benzenesulphonyl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]-2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-4-methylvaleramide in the form of a white solid.

Provenance & Evidence