HCID 86757305, compound → HCID 86757304, compound

HRID 651798Notes

Reaction equation

ONC([C@H]([C@@H](CC(C)C)C(NN1C(=O)C2(CCN(S(C)(=O)=O)CC2)NC1=O)=O)CCCC1C=CC=CC=1)=O.O1CCCCC1[O:45][NH:46][C:47]([C@H:49]([CH:59]([CH2:73][CH:74]([CH3:76])[CH3:75])[C:60]([NH:62][N:63]1[C:67](=[O:68])[C@H:66]([CH2:69][O:70][CH3:71])[NH:65][C:64]1=[O:72])=[O:61])[CH2:50][CH2:51][CH2:52][C:53]1[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=1)=[O:48]>>[OH:45][NH:46][C:47]([C@H:49]([C@@H:59]([CH2:73][CH:74]([CH3:76])[CH3:75])[C:60]([NH:62][N:63]1[C:67](=[O:68])[C@H:66]([CH2:69][O:70][CH3:71])[NH:65][C:64]1=[O:72])=[O:61])[CH2:50][CH2:51][CH2:52][C:53]1[CH:54]=[CH:55][CH:56]=[CH:57][CH:58]=1)=[O:48]

Participants

Reactant 2

HCID 86757305HCID 86757305, compound

HCID 86757306HCID 86757306, compound

Product 1

HCID 86757304HCID 86757304, compound

Procedure

In a manner analogous to that described in Example 3 from 0.561 g of 2(R)-[[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenylbutyl]-N-[4(S)-(methoxymethyl)-2,5-dioxo-1-imidazolidinyl]-4-methylvaleramide there was obtained 0.11 g of 2(R)-[1(S)-(hydroxycarbamoyl)-4-phenylbutyl]-N-[4(S)-(methoxymethyl)-2,5-dioxo-1-imidazolidinyl]-4-methylvaleramide in the form of an off-white solid.

Sources & evidence

ORD record: ord-966a83187e344554b5137fd469dbc5ed
Source dataset: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06281363B1

Reaction notes

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