p-Toluenesulfonic acid monohydrate → HCID 10318924, compound

Participants

Reaction Steps

A solution of 0.298 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-4-methyl-N-(2,4-dioxo-1-imidazolidinyl)valeramide in 3 ml of methanol was treated with 0.030 g of p-toluenesulphonic acid monohydrate. The mixture was stirred for 3.5 hours at room temperature and then diluted with ethyl acetate and washed in sequence with 5% aqueous sodium hydrogen carbonate and saturated aqueous sodium chloride. The organic layer was dried over anhydrous magnesium sulphate and evaporated. The residue was triturated with diethyl ether to give 0.076 g of (E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-4-methyl-N-(2,4-dioxo-1-imidazolidinyl)valeramide in the form of a white solid.

Provenance & Evidence