HuagongsheHuagongshe Chemistry Print Report · For research reference only
2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-2'-[N-(benzyloxycarbonyl)-glycinyl]-4-methylvalerohydrazide → 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-2'-glycinyl-4-methylvalerohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-2'-[N-(benzyloxycarbonyl)-glycinyl]-4-methylvalerohydrazide | HCID 70239547 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-2'-glycinyl-4-methylvalerohydrazide | HCID 86757311 | 98.4% |
Reaction Steps
A solution of 2.95 g of 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-2′-[N-(benzyloxycarbonyl)-glycinyl]-4-methylvalerohydrazide in 30 ml of methanol was hydrogenated in the presence of 0.300 g of 5% palladium-on-carbon for 0.5 hours. The mixture was filtered and evaporated to give 2.2 g of 2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenylbutyl]-2′-glycinyl-4-methylvalerohydrazide in the form of a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06281363B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-de776090e824496c884bd04b95d6a22f |
| Source note | uspto-grants-2001_08 |