p-Toluenesulfonic acid monohydrate → HCID 86757312, compound

Participants

Reaction Steps

A solution of 0.133 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-4-methyl-N-(3-methyl-2,5-dioxo-1-imidazolidinyl)valeramide in 5 ml of methanol was treated with 0.014 g of p-toluenesulphonic acid monohydrate. The mixture was stirred for 2.5 hours at room temperature and then evaporated. The residue was dissolved in ethyl acetate and washed with 5% aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous magnesium sulphate and evaporated. The residue was triturated with diethyl ether and hexane to give 0.049 g of (E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-4-methyl-N-(3-methyl-2,5-dioxo-1-imidazolidinyl)valeramide in the form of a white solid.

Provenance & Evidence