p-Toluenesulfonic acid monohydrate → HCID 86757314, compound

Participants

Reaction Steps

A solution of 0.209 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-4-methyl-N-(3-methyl-5-oxo-2-thioxo-1-imidazolidinyl)valeramide in 5 ml of methanol was treated with 0.020 g of p-toluenesulphonic acid monohydrate. The mixture was stirred for 2.5 hours at room temperature and then evaporated. The residue was dissolved in ethyl acetate and washed with 5% aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous magnesium sulphate and evaporated. The residue was triturated with diethyl ether/hexane (2:1) to give 0.048 g of (E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-4-methyl-N-(3-methyl-5-oxo-2-thioxo-1-imidazolidinyl)valeramide in the form of a yellow solid.

Provenance & Evidence