HCID 86757319, compound → HCID 86757318, compound

Participants

Reaction Steps

A solution of 0.229 g of 2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenylbutyl]-4-methyl-N-(1-methyl-3,5-dioxo-1,2,4-triazolidin-4-yl)valeramide in 20 ml of methanol was hydrogenated in the presence of 0.02 g of 10% palladium-on-carbon for 5 hours. Filtration and evaporation gave a residue which was triturated with diethyl ether to give 0.135 g of 2(R)-[1(S)-(hydroxycarbamoyl)-4-phenylbutyl]-4-methyl-N-(1-methyl-3,5-dioxo-1,2,4-triazolidin-4-yl)valeramide in the form of a white solid.

Provenance & Evidence