HCID 86757325, compound → HCID 86757324, compound

Participants

Reaction Steps

A solution of 1.1 g of N-(3-benzyl-2,5-dioxo-1-imidazolidinyl)-2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenyl-3-butenyl]-4-methylvaleramide in 20 ml of methanol was hydrogenated in the presence of 0.100 g of 10% palladium-on-carbon for 3 hours. The mixture was filtered and evaporated and the residue was triturated with diethyl ether to give 0.444 g of N-(3-benzyl-2,5-dioxo-1-imidazolidinyl)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenylbutyl]-4-methylvaleramide in the form of a white solid.

Provenance & Evidence