Triethylamine → HCID 70204287, compound

Participants

Reaction Steps

A solution of 0.772 g of (E)-2(S)-(tert-butoxycarbonyl)-1(R)-isobutyl-5-phenylpent-4-enyl-1,3,4-oxadiazol-2(3H)-one (prepared as described in Example 34, part (i)) in 10 ml of toluene was treated with 0.387 g of N-benzyl glycine ethyl ester and 0.278 ml of triethylamine and heated overnight at reflux temperature. The mixture was cooled then diluted with ethyl acetate and washed in sequence with 5% aqueous citric acid, 5% aqueous sodium hydrogen carbonate and saturated aqueous sodium chloride and then dried over anhydrous magnesium sulphate. Evaporation gave 0.918 g of N-(3-Benzyl-2,5-dioxo-1-imidazolidinyl)-2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenyl-3-butenyl]-4-methylvaleramide in the form of a white foam.

Provenance & Evidence