O-Benzylhydroxylamine → HCID 86757331, compound

HRID 651825Notes

Reaction equation

HRID 651825 reaction equation
C([O:5][C:6]([C@H:8]([C@@H:18]([CH2:37][CH:38]([CH3:40])[CH3:39])[C:19]([NH:21][N:22]1[C:26](=[O:27])[C:25](=[O:28])[N:24]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:23]1=[O:36])=[O:20])[CH2:9]/[CH:10]=[CH:11]/[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C.[CH2:41]([O:48][NH2:49])[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1.O1CCCCC1ON>>[CH2:41]([O:48][NH:49][C:6]([C@H:8]([C@@H:18]([CH2:37][CH:38]([CH3:40])[CH3:39])[C:19]([NH:21][N:22]1[C:26](=[O:27])[C:25](=[O:28])[N:24]([CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:23]1=[O:36])=[O:20])[CH2:9]/[CH:10]=[CH:11]/[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:5])[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1

Participants

4

Reactant 3

HCID 102313O-BenzylhydroxylamineHCID 5142091O-(Tetrahydropyran-2-yl)hydroxylamineHCID 86757334HCID 86757334, compound

Product 1

HCID 86757331HCID 86757331, compound

Procedure

In an analogous manner to that described in Example 1, parts (vi)-(viii), but using (E)-2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenyl-3-butenyl]-N-(3-benzyl-2,4,5-trioxo-1-imidazolidinyl]-4-methylvaleramide and O-benzylhydroxylamine in place of (E)-2(R)-[1(S)-(tert-butoxycarbonyl)-4-phenyl-3-butenyl]-2′-glycinyl-4-methylvalerohydrazide and O-(tetrahydro-2H-pyran-2(RS)-yl)hydroxylamine respectively there was obtained (E)-2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenyl-3-butenyl]-N-(3-benzyl-2,4,5-trioxo-1-imidazolidinyl]-4-methylvaleramide in the form of a white solid.

Sources & evidence

ORD record
ord-da879a8e34e94683bcee6ad2ad44f1c8
Source dataset
uspto-grants-2001_08
Patent number
US06281363B1

Reaction notes

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