p-Toluenesulfonic acid monohydrate → HCID 86757335, compound

Participants

Reaction Steps

A solution of 0.045 g of (E)-N-(3-benzyl-2,4,5-trioxo-1-imidazolidinyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-4-methylvaleramide in 2 ml of methanol was treated with 0.010 g of p-toluenesulphonic acid monohydrate and stirred at room temperature for 2 hours. The mixture was diluted with ethyl acetate and washed in sequence with 5% aqueous sodium hydrogen carbonate and saturated aqueous sodium chloride. The organic layer was dried over anhydrous magnesium sulphate and evaporated to give a residue which was triturated with diethyl ether to give 0.032 g of (E)-N-(3-benzyl-2,4,5-trioxo-1-imidazolidinyl]-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-4-methylvaleramide in the form of a white solid.

Provenance & Evidence