HCID 131720793, compound → HCID 20439282, compound

HRID 651852Notes

Reaction equation

HRID 651852 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[CH2:2][C:3]([OH:5])=[O:4].[CH2:16]([OH:23])[C:17]([NH2:22])([CH2:20][OH:21])[CH2:18][OH:19]>C(O)C.[Pd]>[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[CH2:16]([OH:23])[C:17]([NH2:22])([CH2:20][OH:21])[CH2:18][OH:19]

Participants

4

Reactant 1

HCID 131720793HCID 131720793, compound

Product 1

HCID 20439282HCID 20439282, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The title compound was prepared by hydrogenation of a solution of Z-Gly-Tris in ethanol at 40 pa. pressure in a Parr hydrogenator in the presence of palladium on carbon (10% ). The removal of the Z group was monitored by HPLC. The catalyst was removed by filtration and washed with ethanol. Evaporation of the solvent gave the title compound in 95% yield. The preparation of Z-Gly-Tris is described in Whittaker, R. G., Hayes, P. J., and Bender, V. J. (1993). Peptide Research 6; 125 and Australian Patent No. 649242.

Workup

  1. customThe removal of the Z group
  2. customThe catalyst was removed by filtration
  3. washwashed with ethanol
  4. customEvaporation of the solvent

Sources & evidence

ORD record
ord-99519c05461840da908052fc48d35be9
Source dataset
uspto-grants-2001_08
Patent number
US06281376B1

Reaction notes

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