HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
L-Glutamic Acid → [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | L-Glutamic Acid | HCID 33032 | — |
| Edukt | Methotrexate | HCID 126941 | — |
| Produkt | [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid | HCID 70031183 | — |
Reaktionsschritte
The title compound was prepared by carboxypeptidase G cleavage of glutamic acid from methotrexate as described in the literature (J. Med. Chem. 24, 1450-1455 (1981)). The yield of I obtained was virtually quantitative.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06281376B1 |
| Quelldatensatz | uspto-grants-2001_08 |
| ORD ID | ord-39cc6343f5f141b9a3665e4ee56b3657 |
| Quellennotiz | uspto-grants-2001_08 |