Trifluoroacetic acid → HCID 178521307, compound

Participants

Reaction Steps

To a solution of the trityl compound from Step 4 above (0.49 g) in DCM (10 mL) was added TFA (10 mL). The solution was stirred at room temperature for 2 hours and then concentrated. The residue was dissolved in DCM and washed with saturated aqueous NaHCO3. The aqueous layer was extracted with DCM (2×50 mL). The combined organic extracts were dried over MgSO4 and concentrated. Flash chromatography (10% MeOH in DCM) gave 0.22 g (50% yield over two steps) of the title compound as a white foam.

Provenance & Evidence