Hydrochloric Acid → p-Fluorophenylbuty phosphonic acid

Participants

Reaction Steps

To a solution of p-fluorophenylbutyl phosponous acid (1 g, 0.0046 mole) in acetone (10 ml) and water (10 ml) was added a solution of sodium hydroxide (0.185 g, 0.0046 mole) in water (5 ml) until a pH of 7 was reached. A solution of KMnO4 (0.44 gm, 0.0028 mole) in water (50 ml) was added slowly to the vigorously stirred solution of phosphonous acid at 20-25° C. After the addition (20 min), the reaction mixture was stirred for 10 min at ambient temperature and acidified with concentrated HCl acid until a pH 1 was reached. Saturated sodium bisulphite solution was added to the reaction mixture thereby resulting in formation of a cloudy white precipitate.

Provenance & Evidence