反应详情

Cholesterol (19.3 gms) and dichlorodicyanoquinone (38 gms) in dry dioxan (500 ml) were heated under reflux for 22 hrs. The mixture was then cooled, filtered and the filtrate evaporated to dryness. Chromatography of the residue on alumina and elution with benzene/hexane followed by elution with benzene afforded the trienone as a pale oil (11.5 gms) which solidified on standing. Physical properties of this material were appropriate.

1. temperatureunder reflux for 22 hrs
2. temperatureThe mixture was then cooled
3. filtrationfiltered
4. customthe filtrate evaporated to dryness
5. washChromatography of the residue on alumina and elution with benzene/hexane
6. washfollowed by elution with benzene