1,3-Dibromo-5,5-dimethylhydantoin → HCID 13911115, compound

Participants

Reaction Steps

A solution of the dibenzoate described in (a) (0.58 gms) in hexane (10 ml) was treated with dibromodimethylhydantoin (0.15 gms) and heated under reflux for 25 mins. After cooling the mixture was filtered and the filtrate concentrated to a pale oil. The oil was dissolved in dry xylene (3 mls) and added dropwise to a refluxing solution of trimethylphosphite (0.4 ml) in xylene (5 ml.). Heating under reflux continued for 1.75 hrs. after which time the solvents were removed under reduced pressure and the residue crystallized from acetone/methanol to give the title compound. Recrystallized from ethanol/acetone the product had melting point 161°-162°⟦alpha⟧sub.D -8°.

Provenance & Evidence