Sodium Hydroxide → HCID 13747172, compound

HRID 651967Notes

Reaction equation

HRID 651967 reaction equation
[CH2:1]([NH:4][C:5]1[C:10](C(OCC)=O)=[CH:9][N:8]=[C:7]2[CH:16]=[N:17][NH:18][C:6]=12)[CH:2]=[CH2:3].[OH-].[Na+]>C(O)C>[CH2:1]([NH:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:16]=[N:17][NH:18][C:6]=12)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13747174HCID 13747174, compound

Product 1

HCID 13747172HCID 13747172, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 7-Allylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (D10) (1.0 g 0.004 mole) was converted to the corresponding acid by heating under reflux with a 2% sodium hydroxide solution in ethanol (50 ml). The ethanol was removed under reduced pressure, and the residue diluted with water (10 ml) and acidified to pH5 with dilute hydrochloric acid. The resulting acid was filtered and dried, m.p. 230°-232° C.

Workup

  1. temperatureby heating
  2. customThe ethanol was removed under reduced pressure
  3. additionthe residue diluted with water (10 ml)
  4. filtrationThe resulting acid was filtered
  5. customdried

Sources & evidence

ORD record
ord-46d6d6a1260b49b891898df7f4495c59
Source dataset
uspto-grants-1987_06
Patent number
US04670432

Reaction notes

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