HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Cyclopropyl-5-(isocyanomethyl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | N-((3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl)formamide | HCID 14460538 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Cyclopropyl-5-(isocyanomethyl)-1,2,4-oxadiazole | HCID 22912924 | — |
Reaction Steps
A stirred solution of 3-cyclopropyl-5-formylaminomethyl-1,2,4-oxadiazole (60 mmol) and triethylamine (176 mmol) in CH2Cl2 (100 ml) was charged at 0° C. dropwise with POCl3 (60 mmol). The mixture was then left for 30 min. with stirring at 0° C., whereafter a solution of Na2CO3 (60 mmol) in H2O (50 ml) was added. The mixture was heated to room temperature, whereafter the organic phase was separated, dried and evaporated in vacuo. The residue was treated with ether, decanted, and the solution was evaporated to give the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04670433 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-e8beecc2ebbf41309d24b738ce039917 |
| Source note | uspto-grants-1987_06 |