Water → HCID 20199000, compound

Participants

Reaction Steps

In a round-bottomed 1000 ml. flask 20 g. of 1-ethyl-4-oxo-6-fluoro-7-(piperazinyl)-1,4-dihydro-quinoline-3-carboxylic acid are suspended in a mixture of 150 ml. methanol and 50 ml. distilled water. From a dropping funnel 18 ml. of N,N,N-trimethyl-2-hydroxyethyl-ammonium hydroxide (choline base) dissolved in 50% methanol are added dropvise to the suspension under constant stirring at room temperature. A clear, light yellow solution is obtained. The aqueous-methanolic solution is evaporated above 40% water bath in vacuo. The yellow, adhesive solution thus obtained is suspended in 200 ml of acetone and heated to boiling, then isopropanol (36 ml.) is added dropwise under boiling until total dissolution. The solution is cooled slowly. The precipitated material is filtered under vacuo on a glass filter G-4 and washed. Wet-weight after filtration: 27.4 g.

Provenance & Evidence