5-Amino-6-(2-methoxy-4-methanesulfonylaminobenzoyl-amino)-2-pyridone → HCID 178493306, compound

HRID 651987Notes

Reaction equation

HRID 651987 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5](=[O:24])[NH:6][C:7]=1[NH:8][C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][C:11]=1[O:21][CH3:22]>C(O)(=O)C>[CH3:22][O:21][C:11]1[CH:12]=[C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH:14]=[CH:15][C:10]=1[C:9]1[N:8]=[C:7]2[NH:6][C:5](=[O:24])[CH2:4][CH:3]=[C:2]2[N:1]=1

Participants

3

Reactant 1

HCID 212957955-Amino-6-(2-methoxy-4-methanesulfonylaminobenzoyl-amino)-2-pyridone

Product 1

HCID 178493306HCID 178493306, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2.7 g of 5-amino-6-(2-methoxy-4-methanesulfonylaminobenzoyl-amino)-2-pyridone were refluxed in 50 ml of glacial acetic acid for 1.5 hours. The mixture was then concentrated by evaporation in vacuo, and the residue was purified on silica gel (eluant: methylene chloride/ethanol 1:0 to 1:0.1).

Workup

  1. concentrationThe mixture was then concentrated by evaporation in vacuo
  2. customthe residue was purified on silica gel (eluant: methylene chloride/ethanol 1:0 to 1:0.1)

Sources & evidence

ORD record
ord-b5526f17b2d54921bad4bc609564f11a
Source dataset
uspto-grants-1987_06
Patent number
US04670438

Reaction notes

Loading…