HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl DL-serinate → N-cyclohexyl-N-methyl-4-(2-oxo-3-hydroxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl DL-serinate | HCID 416960 | — |
| Reactant | (S)-methyl 2-amino-3-hydroxypropanoate | HCID 2723731 | — |
| Reactant | N-cyclohexyl-N-(2-acetoxyethyl)-4-(4-nitro-3-(1-oxoeth-1-yl)phenyl)oxybutanamide | HCID 20198535 | — |
| Product | N-cyclohexyl-N-methyl-4-(2-oxo-3-hydroxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutanamide | HCID 135626245 | — |
Reaction Steps
Proceeding in a like manner but substituting the appropriate aldehyde of formula (6) as prepared in Preparation 4, or the appropriate ketone of formula (8) as prepared in either Preparation 6 or 9, and either L-serine methyl ester or a racemic mixture of D,L-serine methyl ester or similar ester, there are prepared the following exemplary compounds:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04670434 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-4820e9f66bda4ce3a21677e825ebff7d |
| Source note | uspto-grants-1987_06 |