Sulfuric Acid → HCID 135626237, compound

HRID 652003Notes

Reaction equation

HRID 652003 reaction equation
C(O)(=O)C.[CH2:5]([N:12]([CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:13](=[O:33])[CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[N:24]=[C:23]1[NH:28][C:29](=[O:32])[C:30](=C)[N:22]1[CH2:21]2)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[S:41](=[O:45])(=[O:44])([OH:43])[OH:42]>O>[S:41]([OH:45])([OH:44])(=[O:43])=[O:42].[CH2:34]([N:12]([CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[C:13](=[O:33])[CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[N:24]=[C:23]1[NH:28][C:29](=[O:32])[CH2:30][N:22]1[CH2:21]2)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 135626329HCID 135626329, compound

Product 1

HCID 135626237HCID 135626237, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N,N-dibenzyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutanamide acetate (1.0 g) is dissolved in 50 ml water containing a stoichiometric equivalent of sulfuric acid, and the solution evaporated to dryness. The product is suspended in ethanol and filtered, air dried and recrystallized from methanol/acetone to yield N,N-dibenzyl-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutanamide sulfate.

Workup

  1. customthe solution evaporated to dryness
  2. filtrationfiltered
  3. customair dried
  4. customrecrystallized from methanol/acetone

Sources & evidence

ORD record
ord-7eb5d484d497434e82f3d394c8f507d9
Source dataset
uspto-grants-1987_06
Patent number
US04670434

Reaction notes

Loading…