HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-(Methoxycarbonyl)propyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl 2-hydroxybutanoate | HCID 520445 | — |
| Reactant | 4-[14-(Trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride | HCID 20198230 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(Methoxycarbonyl)propyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate | HCID 20198267 | — |
Reaction Steps
To a solution of 10.0 g. 4-[14-(trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride in 200 ml. methylene chloride is added dropwise a solution of 3 g. methyl α-hydroxybutyrate and 5 g. triethylamine in 100 ml. ether. After 17 hours stirring at room temperature, the precipitate is collected and washed with several portions of ether. The ether solution is washed with water, dried and evaporated to yield the product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04670421 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-703c8991bd5548c08ffbd47fb47e00ab |
| Source note | uspto-grants-1987_06 |