反应详情

A solution of 12.3 g. of 4-[14-(trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride and 2.8 g. of methanesulfonamide in 150 ml. of pyridine is stirred at reflux for 2 hours and then evaporated in vacuo. The residue is partitioned between water and diethyl ether, the aqueous layer acidified with 1N hydrochloric acid, and the organic layer separated, dried with magnesium sulfate and evaporated. Crystallization of the residue affords the product as a white solid.

1. temperatureat reflux for 2 hours
2. customevaporated in vacuo
3. customThe residue is partitioned between water and diethyl ether
4. customthe organic layer separated
5. dry with materialdried with magnesium sulfate
6. customevaporated
7. customCrystallization of the residue