Sodium Hydroxide → HCID 20198306, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture containing 4.2 g. of 1-[4-[N-(tert-butyloxycarbonyl)-4-[14-(trimethylsilyl)tetradecylamino]benzoyl)imidazole, 50 ml. of chloroform, and 50 ml. of 5N sodium hydroxide is added 1.1 g. of 3-amino-1,2-propanediol. The solution is vigorously stirred for 24 hours, the layers are separated, and the chloroform solution is washed once with 50 ml. of 1N sodium hydroxide. The solvent is evaporated and the residue is heated for 30 minutes at 40° C. in 50 ml. of anhydrous trifluoroacetic acid. The solvent is again evaporated and the oil is crystallized to yield the product as a light yellow solid.

Provenance & Evidence