HCID 18608089, compound → HCID 18608090, compound

Participants

Reaction Steps

3-[3(R)-ethenyl-4(R)-piperidyl]-1-(6-methoxy-4 quinolyl)-1(RS)-propanamine (1.2 g) dissolved in absolute ethanol (25 ml) is hydrogenated at atmospheric pressure and at room temperature in the presence of palladium (0.25 g, 10% on carbon). The absorption of hydrogen is complete in 2 hours. The catalyst is filtered off, the solvent is evaporated under reduced pressure, and the residue is recrystallised from isopropanol. 3-[3(R)-Ethyl-4(R)-piperidyl]-1-(6-methoxy-4 quinolyl)-1(RS)-propanamine is thus obtained as the trihydrochloride, m.p. 200° C.

Provenance & Evidence