反应详情

4.3 g of cyclopropylamine were added dropwise to a solution of 24.9 g of ethyl 2-(2,4-dichloro-5-fluoro-benzoyl)-3-ethoxy-acrylate in 80 ml of ethanol while cooling with ice and stirring. When the exothermic reaction had ceased, the mixture was stirred for another hour at room temperature, the solvent was stripped off in vacuo, and the residue was recrystallised from cyclohexane/petroleum ether. 22.9 g of ethyl 2-(2,4-dichloro-5-fluoro-benzoyl)-3-cyclopropylamino-acrylate (R1 =C2H5) of melting point 89° to 90° C. were obtained.

1. temperaturewhile cooling with ice
2. customWhen the exothermic reaction
3. stirringthe mixture was stirred for another hour at room temperature
4. customthe residue was recrystallised from cyclohexane/petroleum ether