HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 652057Generated: October 25, 2026
Hydrochloric Acid → 4-Ethyl-5-pyridin-4-yl-2(3H)thiazolone
https://huagongshe.com/reaction/652057
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Acetylthiourea | HCID 2723593 | — |
| Reactant | Potassium cyanate | HCID 11378442 | — |
| Reactant | 1-(4-Pyridyl)-1-bromo-2-butanone | HCID 20199218 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Ethyl-5-pyridin-4-yl-2(3H)thiazolone | HCID 20145016 | — |
Reaction Steps
1-(4-Pyridyl)-1-bromo-2-butanone (28.8 g, 0.1 mol) and 1-acetyl-2-thiourea (13.0 g, 0.11 mol) are combined in 200 ml absolute ethanol and refluxed 24 hours. The solvent is evaporated and the residue is purified by chromatography. The thiol is mixed with (8.1 g, 0.1 mol) potassium cyanate and 0.2 mol 10% aqueous hydrochloric acid. The mixture is heated to 80° C. for 15 minutes, then cooled. The acid is adjusted to ph=6.5 with solid sodium bicarbonate which causes the product to precipitate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04670450 |
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| Source dataset | uspto-grants-1987_06 |
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| ORD ID | ord-59335595239343ebbaf7e4fe817cfef8 |
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| Source note | uspto-grants-1987_06 |
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