Ethanol → 1,3-Dimethyl-5-[4-chloro-2-(2,6-dichlorophenoxy)phenylcarbamoyl]-2-thiobarbituric acid

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Reaction Steps

2.5 g (10 mmol) of 1,3-dimethyl-5-ethoxycarbonyl-2-thiobarbituric acid, 2.9 g (10 mmol) of 4-chloro-2-(2,6-dichlorophenoxy)aniline, 40 ml of ethanol and 3 ml of dimethylformamide are mixed and then boiled under reflux with stirring for 6 hours. The reaction mixture is then cooled and the resultant crystalline precipitate is isolated by filtration. If necessary, the crystalline precipitate can be recrystallised from a mixture of dioxane and ethanol. Melting point 254°-257° C.

Provenance & Evidence