Acetic Anhydride → HCID 20199120, compound

HRID 652091Notes

Reaction equation

HRID 652091 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][N:9]1[C:13]([NH:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)[CH:20]=2)=[N:12][C:11]([CH2:32][NH2:33])=[N:10]1>N1C=CC=CC=1>[CH3:8][N:9]1[C:13]([NH:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]3[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]3)[CH:20]=2)=[N:12][C:11]([CH2:32][NH:33][C:1](=[O:3])[CH3:2])=[N:10]1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20199116HCID 20199116, compound

Product 1

HCID 20199120HCID 20199120, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of acetic anhydride (0.089 g) in dry pyridine (1 ml) was added dropwise to a solution of 1-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-1H-1,2,4-triazole-3-methanamine (A) (0.31 g) at 5°. The solution was stirred at room temperature for 0.5 h, and the solvent was removed under reduced pressure to leave a yellow oil which was triturated with light petroleum b.p. 60°-80° to give the title compound as a white solid (0.27 g), m.p. 123°.

Workup

  1. customthe solvent was removed under reduced pressure
  2. customto leave a yellow oil which
  3. customwas triturated with light petroleum b.p. 60°-80°

Sources & evidence

ORD record
ord-581888262c5d4c7d89dd01ba608edab5
Source dataset
uspto-grants-1987_06
Patent number
US04670448

Reaction notes

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