Ethanol → HCID 137175503, compound

Participants

Reaction Steps

A solution of hydroxylamine hydrochloride (0.36 g) in ethanol (20 ml) was treated with potassium hydroxide (0.28 g). A solution of 1-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-1H-1,2,4-triazole-3-carboxaldehyde (A) (1.5 g) in ethanol (20 ml) was added. The mixture was stirred for 15 minutes and then filtered. The filtrate was evaporated and the residue was dissolved in chloroform and washed with water. The organic solution was dried, filtered and evaporated and the solid residue was dissolved in ethyl acetate/ethanol and treated with a solution of fumaric acid in ethyl acetate/ethanol, to give the title compound (0.05 g) m.p. 173°-4°.

Provenance & Evidence