Malonic Acid → HCID 70435416, compound

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Reaction Steps

A solution of 1-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-1H-1,2,4-triazole-3-carboxaldehyde (0.8 g), malonic acid (0.23 g), piperidine (0.05 ml) and pyridine (5 ml) was heated at 90° for 4 h. The resulting solution was azeotroped with toluene to give a brown foam (0.9 g) which was partitioned between aqueous sodium hydroxide and diethyl ether. The aqueous layer was acidified (pH 5.5) to precipitate the title compound (0.4 g) as a white solid, m.p. 95°-100° [decomp].

Provenance & Evidence