Methanesulfonyl chloride → HCID 12774379, compound

HRID 652104Notes

Reaction equation

HRID 652104 reaction equation
[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)=[N:5][C:4]([CH2:25][NH2:26])=[N:3]1.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>N1C=CC=CC=1>[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]3)[CH:13]=2)=[N:5][C:4]([CH2:25][NH:26][S:28]([CH3:27])(=[O:30])=[O:29])=[N:3]1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 20199116HCID 20199116, compound

Product 1

HCID 12774379HCID 12774379, compoundYield 23%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 1-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-1H-1,2,4-triazole-3-methanamine (0.5 g) and methane sulphonyl chloride (0.16 g) in pyridine (25 ml) was stirred at room temperature for 18 h. The solution was evaporated to give a brown oil which was crystallised from a mixture of ethyl acetate and petroleum ether (b.p. 60°-80°) to give the title compound (0.14 g) as a white powder, m.p. 117°-118°.

Workup

  1. customThe solution was evaporated
  2. customto give a brown oil which
  3. customwas crystallised from a mixture of ethyl acetate and petroleum ether (b.p. 60°-80°)

Sources & evidence

ORD record
ord-81863c1cd82a41abb758afc40b0713fe
Source dataset
uspto-grants-1987_06
Patent number
US04670448

Reaction notes

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